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Sunday, February 12, 2012
12 Wind-Slipping Designs from the Father of Streamlining [Design]
Saturday, February 11, 2012
Will the No Child Left Behind Act Get Left Behind? (ContributorNetwork)
COMMENTARY | The Obama administration announced today that 10 states will get a waiver from the stringent requirements of the Bush-era "No Child Left Behind Act." It's the beginning of the end for NCLB, unless Congress passes a bipartisan reform of the controversial education law.
Critics of Obama's decision cried foul. Minnesota Congressman John Kline, whose state was one that sought and received a waiver, claimed Obama was imposing his will on them, while the president merely allowed states more flexibility to meet the standards in the best way they see fit.
Obama contended NCLB was well-intentioned, though poorly executed. But Republican opponents are sure to see this as a case of a president from one party undoing the popular work of a prior president. It would wipe away the Bush legacy.
But the states sought the waivers. Of the 11 states that sought waivers, seven are led by Republican governors. Another on that list voted for John McCain in 2008. This is hardly a plot solely hatched by Democrat governors to embarrass George W. Bush.
The list of states that are seeking relief encompasses the political spectrum. According to the Gallup Polling firm's analysis of state ideologies (from most conservative to least conservative) these NCLB waiver states include Oklahoma (seventh most conservative) to Tennessee (10th), Georgia (17th), Indiana (19th), Kentucky (22nd), Colorado (27th), Florida (28th), Minnesota (33rd), New Jersey (46th) and Massachusetts. New Mexico (29th) applied for a waiver, and is working with the Obama administration to revise it. Liberal, moderate and conservative states are united against NCLB.
Nor is this waiver policy simply election-year politics. According to Georgia State School Superintendent John Barge, this process began last year. Waivers had to be revised to meet standards. Many of these states pushing for reform also received or sought "Race to the Top" grants.
Critics of Obama's flexibility approach to state education policy might claim this just represents only 11 states. But another 28 states, the District of Columbia and Puerto Rico have also said they plan to seek waivers, and three other populous states are considering it.
A bipartisan compromise could rescue NCLB with a series of much-needed reforms. Democrats seem willing, but angry Republicans like Kline seem to leave no room for negotiation, bitter that Obama's plan goes around Congress. And that will only hasten the demise of NCLB, Bush's most enduring piece of legislation.
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Friday, February 10, 2012
Adele Should Win Big At Grammys, Brandy And Monica Say
Legendary producer Clive Davis agrees, calling this 'the year of Adele.'
By Kelley L. Carter
Adele
Photo: Jon Furniss/ WireImage
No doubt about it, it's been the year of Adele. And when one of music's most respected figures says it, you can't help but agree.
Legendary record producer and music executive Clive Davis sat and talked with R&B singers Brandy and Monica on Thursday, and they were all on the same page when it came to who they wanted to see take home the big prizes at the Grammy Awards on Sunday night.
They're fans of Rihanna, but they'd love British singer Adele to win the Grammy for Album of the Year. Both singers are up for the big prize, along with Lady Gaga, Bruno Mars and the Foo Fighters.
"You know, it's so hard because to me you can't really choose one person when you know about both of their journeys. Rihanna is somebody I love because she's OK with self. That's something that's always been resonated through her and her music," Monica said. "I play 'You Da One' all day. When I think about my husband I play 'You Da One.'
"But Adele's voice is so amazingly beautiful," Monica continued. "And the fact that she embodies the soul that you [talking to mentor Davis] used to tell me in the early '90s not to be afraid of ... He used to say, 'Sing it big, sing it strong.' Looking at her, she does that every time she hits the stage."
Davis added that Adele brings back that old soul, and he appreciates her big voice and style of music.
"All the nominees — it's a worthy thing to get nominated, but this has been the year of Adele," Davis said. "No disrespect to any other nominee. In this era where there is perhaps too much electronica and dance music ... I love it. It's inventive, but it should not be the totality of what is exposed. She has just come back with pure music. Just throwing her head back and singing out with full voice, but songs that resonate as well."
Davis continued, saying, "It's been an incredible impact on music and worthy of being singled out, as I'm sure it will be."
As for Brandy, she's tossing her support behind the singer that her daughter Sy'rai adores. Naturally, it's Adele.
"My daughter is in love with Adele. She listens to her every day," Brandy said. "To see someone with that much passion and soul move a 9-year-old is amazing and it's magical."
Chaos! Profanity! Wardrobe malfunctions! Don't miss Sway and James Montgomery live from the Grammys red carpet this Sunday, February 12, for a full three hours of mayhem, starting at 5 p.m. ET on MTV.com. And the fun doesn't end Sunday: MTV News has you covered until the Grammy hangover wears off!
Related Videos Related Photos Related ArtistsSource: http://www.mtv.com/news/articles/1678936/grammys-adele-brandy-monica.jhtml
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Nanotube therapy takes aim at breast cancer stem cells
Wake Forest Baptist Medical Center researchers have again proven that injecting multiwalled carbon nanotubes (MWCNTs) into tumors and heating them with a quick, 30-second laser treatment can kill them.
The results of the first effort involving kidney tumors was published in 2009, but now they've taken the science and directed it at breast cancer tumors, specifically the tumor initiating cancer stem cells. These stem cells are hard to kill because they don't divide very often and many anti-cancer strategies are directed at killing the cells that divide frequently.
The Wake Forest Baptist research findings are reported online ahead of April print publication in the journal Biomaterials. The research is a result of a collaborative effort between Wake Forest School of Medicine, the Wake Forest University Center for Nanotechnology and Molecular Materials, and Rice University. Lead investigator and professor of biochemistry Suzy V. Torti, Ph.D., of Wake Forest Baptist, said the breast cancer stem cells tend to be resistant to drugs and radiotherapy, so targeting these particular cells is of great interest in the scientific community.
"They are tough. These are cells that don't divide very often. They just sort of sit there, but when they receive some sort of trigger ? and that's not really well understood ? it's believed they can migrate to other sites and start a metastasis somewhere else," Torti explained. "Heat-based cancer treatments represent a promising approach for the clinical management of cancers, including breast cancer."
Using a mouse model, the researchers injected tumors containing breast cancer stem cells with nanotubes, which are very small tubes made of carbon. By themselves, said Torti, nanotubes don't have any anti-tumor properties, but if they are exposed to laser-generated, near-infrared radiation they start to vibrate and produce heat. This combination can produce a local region in the tumor that is very hot, she said. Using this method, the group was able to stop the growth of tumors that were largely composed of breast cancer stem cells. This suggests that nanotube-mediated thermal treatment can eliminate both the differentiated cells that constitute the bulk of the tumor and the cancer stem cells that drive tumor growth and recurrence.
"To truly cure a cancer, you have to get rid of the entire tumor, including the small population of cancer stem cells that could give rise to metastasis," Torti said. "There's more research to be done. We're looking at five to 10 years of more study and development. But what this study shows is that all that effort may be worth it ? it gives us a direction to go for a cure."
Source : Wake Forest Baptist Medical Center
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Thursday, February 9, 2012
Foo Fighters Producer Sheds Light On Grammy Nominee
Butch Vig tells MTV News he's 'really proud' of Wasting Light, up for Album of the Year at Sunday's Grammys.
By James Montgomery
Foo Fighters' Dave Grohl and Nate Mendel
Photo: Peter Wafzig/ Getty Images
Over the past two decades, Butch Vig has produced albums like Nevermind, Siamese Dream and 21st Century Breakdown (to name just a few), and yet he's never helmed a project quite like the Foo Fighters' Wasting Light. Recorded — and mastered — entirely on tape, in Dave Grohl's garage, it was a deliberately anachronistic disc that not only helped rejuvenate the Foos themselves, but was the kind of Herculean undertaking Vig won't forget anytime soon.
And, in recognition of that undertaking — and the rave reviews Wasting Light has earned since being released last year — the Foos head into Sunday's 54th Grammy Awards with six nominations, including a nod for the night's biggest prize: Album of the Year. And in the lead-up to the show, Vig (whose work on the disc earned him a Producer of the Year nom) took time to look back on the making of Light, both the good — and the bad.
"I'm really proud of it. Even though it was in the garage and it was a lot of hard work doing it to tape, we had so much fun recording with Dave and the Foos. It's one of the most fun albums I've worked on in my whole career," he told MTV News. "There was something about making it, where every day was by the seat of your pants, but between the vibe of the band and the songs, God, we laughed a lot. Dave is one of the hardest-working men I know, but he loves to f--- around. He'd be playing some guitar part and his daughter would walk in and he'd start making goofy faces, and we're all on the floor. And he's still playing the part f---ing perfect. He definitely embraced it. To be honest, I didn't want it to end."
Of course, that doesn't mean there weren't a few setbacks along the way. Basically everything about Wasting Light created challenges at one point or another — including Grohl's "no computers or else" edict.
"I've recorded hundreds of records on tape, but I haven't for over 10 years, so when Dave told me he wanted to do it that way, I looked him in the eye and said, 'OK, we can do this,' but I thinking, 'Oh sh--, oh sh--' the whole time," Vig laughed. "And I started talking to our engineer, and he was like, 'OK, we'll record on tape, and then we'll finish everything in ProTools.' And then Dave said, 'There are no computers in the studio. If I see a computer, I'm going to firebomb it and throw it out the window.'
"So, we knew it was going to be tape the entire process, and it was kind of crazy. Just the nature of that process forces you to completely rethink how you're going to do everything," he continued. "And the band has to be great, because you can't fix anything. I've had a couple of younger bands come up to me and say, 'Hey, Butch, do you think you want to do [another album on] tape?' And my answer is always the same: 'Only if you can play as good as the Foo Fighters.' "
And though he finished work on the disc more than a year ago, Vig said he still can't help listening to Light ("My daughter is always playing it around the house, and my wife has it in her car constantly, so I'm still being inundated by it," he laughed), which is rare for him. Then again, there are few albums he's as proud of as this one, and not just because it scored a boatload of Grammy noms. It's the memories he has from making the record that will stay with him forever — most notably, the making of standout track "I Should Have Known," which brought him, Grohl and former Nirvana bassist Krist Novoselic back together for the first time in nearly 20 years.
"To me, that song is definitely the darkest moment on the album, but I kind of find it exhilarating when I listen to it. I remember Dave was sitting a foot away from me when he sang it, and the whole vocal take [on the album] is the first performance he did," Vig said. "And I just remember the hair on the back of my neck going up, going, 'This is happening right now, he means all these words, they're about people he's known that he's lost.' ... And I still feel that way when I hear it now.
"And, of course, after Krist finished his bass overdub, we sat and talked for about three or four hours. Dave and I split a bottle of wine; I think Krist drank about a half a bottle of whiskey. And it was great, because we were talking about when we were recording Nevermind," he continued. "Not so much the actual song recording, but, like, driving over the hill to go see the Butthole Surfers, and Krist was driving after he'd had about a half a bottle of whiskey, and I'm going, 'Dude, pull over, I gotta drive!' and then Kurt seeing Rick Rubin at the Buttholes show and running up to him and pretending to shag his leg. It was a great experience having them both in the room, one I'll never forget."
Chaos! Profanity! Wardrobe malfunctions! Don't miss Sway and James Montgomery live from the Grammys red carpet this Sunday, February 12, for a full three hours of mayhem, starting at 5 p.m. ET on MTV.com. And the fun doesn't end Sunday: MTV News has you covered until the Grammy hangover wears off!
Related Videos Related Photos
Source: http://www.mtv.com/news/articles/1678790/foo-fighters-wasting-light-grammy.jhtml
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Gene Research Offers Clues to Parkinson's Disease (HealthDay)
TUESDAY, Feb. 7 (HealthDay News) -- In certain people with Parkinson's disease, mutations in the parkin gene disrupt the proper function of dopamine, the brain chemical that controls body movement.
The finding could lead to new treatments and screening methods for the disease, according to the University at Buffalo researchers.
Using live human neurons in the laboratory, the team found that parkin mutations hinder the actions of dopamine and produce more "free radicals," harmful molecules that destroy dopamine-laden brain cells, leading to Parkinson's disease.
"Once parkin is mutated, it can no longer precisely control the action of dopamine, which supports the neural computation required for our movement," study author Jian Feng, a professor of physiology and biophysics in the university's School of Medicine and Biomedical Sciences, said in a university news release.
The parkin mutation is responsible for only a small percentage of Parkinson's disease cases, Feng stressed. Nevertheless, understanding how parkin works is relevant to all Parkinson's patients, he said.
One expert agreed that the finding may not be of direct help to most Parkinson's patients at this time.
"One should be cautious in overstating the importance of this since most cases of idiopathic [arising from unknown cause] Parkinson's disease are not caused by parkin mutations," explained Dr. Andrew Feigin, director of the experimental therapeutics division of the Center for Neurosciences at The Feinstein Institute for Medical Research in Manhasset, N.Y. However, he added that, "the creation of human neurons containing a parkin mutation may provide a new means for screening potential therapies for Parkinson's disease."
The study appears in the current issue of the journal Nature Communications.
The researchers said this is the first study to use live human neurons to investigate the role that parkin plays in Parkinson's disease, and it was made possible by the use of stem cells.
The research team created human neurons using human skin cells taken from four people: two with a rare type of Parkinson's disease in which their disease is caused by the parkin mutation, and two with healthy people who served as controls.
There is no cure for Parkinson's disease, which affects at least 500,000 people in the United States.
More information
We Move has more about Parkinson's disease.
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Wednesday, February 8, 2012
Reports: 29 Chinese workers held in Sudan to leave (AP)
BEIJING ? Twenty-nine Chinese workers abducted by rebels in Sudan more than a week ago have been released and were boarding a Red Cross plane to leave rebel territory Tuesday, state media said.
Rebels from the Sudan People's Liberation Movement-North attacked a road construction site on Jan. 28. Of the 47 Chinese who worked there, 29 were taken hostage, 17 managed to escape and one died.
Xinhua News Agency reported the abducted Chinese workers were boarding a plane from the International Committee of the Red Cross, and state broadcaster CCTV said all 29 had been released. No other details of their release were provided.
An official with the Foreign Ministry said it would look into the report. ICRC spokesman Jean-Yves Clemenzo in Geneva said the group would not comment immediately because of the sensitivity of the matter.
Xinhua said the Red Cross was mediating between officials in the capital Khartoum and the Sudan People's Liberation Movement-North, a branch of a guerrilla movement that has fought various regimes in Khartoum for decades. Its members hail from a minority ethnic group now in control of much of South Sudan, which became the world's newest country six months ago in a breakaway from Sudan.
Sudan has accused South Sudan of arming pro-South Sudan groups in the South Kordofan region, where the Chinese workers' camp was located. The government of South Sudan says the accusations are a smoke screen intended to justify a future invasion of the South.
Chinese companies have invested heavily in Sudanese oil production. South Sudan and Sudan are in a bitter dispute over oil, which is produced primarily in South Sudan but runs through Sudanese pipelines for export.
___
Associated Press writer Frank Jordans in Geneva contributed to this report.
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